This applies to both SQL Server stand-alone and SQL Server failover cluster installations (FCI). System databases (master, model, MSDB, and tempdb), and Database Engine user databases can be installed with Server Message Block (SMB) file server as a storage option. Review this support article for more information: Antivirus software on computers running SQL Server.
You might need to configure scanning software, such as antivirus and antispyware applications, to exclude SQL Server folders and file types.
Program files and data files cannot be installed on a removable disk drive, cannot be installed on a file system that uses compression, cannot be installed to a directory where system files are located, and cannot be installed on shared drives on a failover cluster instance.
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